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Highly Sensitive Circular PCF based SPR Biosensor for Early Blood Cancer Detection

Students & Supervisors

Student Authors
Zahid Hasan Rifat
Masters in Electrical and Electronic Engineering, FE
Md. Shihab Sharar Oyon
Masters in Electrical and Electronic Engineering, FE
Md. Abdullah Nabil
Masters in Electrical and Electronic Engineering, FE
Sami-ul Islam Nahid
Masters in Electrical and Electronic Engineering, FE
Supervisors
Prof. Dr. Mohammad Nasir Uddin
Professor, Head [graduate Program], FE
Dr. Md. Kabiruzzaman
Assistant Professor, Faculty, FE

Abstract

Surface Plasmon Resonance (SPR) sensors with Photonic Crystal Fibers (PCF) combine strong plasmonic confinement with flexible light guiding. This combination offers label free, real time Refractive Index (RI) detection, which is critical for early stage cancer diagnostics and biochemical monitoring. In this study, a circular PCF SPR architecture is designed for simple polarization independent operation. Finite element simulations in commercially available software, COMSOL, reveal core guided (X and Y) and Surface Plasmon Polarization (SPP) modes, with a measurable confinement loss peak shift between normal Jurkat cells, RI of 1.376, and cancerous Jurkat cells, RI of 1.39. From this shift, 17,857.14 nm/RIU of wavelength sensitivity, and-711.151 per RIU of amplitude sensitivity were gained. These sensitivities surpass those of prior PCF SPR designs. The circular geometry facilitates straightforward fabrication without compromising performance, demonstrating the sensor’s potential for rapid and high resolution blood cancer detection.

Keywords

PCF SPR blood cancer biosensor COMSOL

Publication Details

  • Type of Publication:
  • Conference Name: 2025 IEEE International Conference on Power, Electrical, Electronics and Industrial Applications (PEEIACON)
  • Date of Conference: 04/12/2025 - 04/12/2025
  • Venue: Southeast University (SEU)
  • Organizer: IEEE and IAS
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