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Highly Sensitive Dual-Mode PCF-SPR Biosensor for Rapid Detection of PC-12 Adrenal Cancer Cell

Students & Supervisors

Student Authors
Md. Shihab Sharar Oyon
Masters in Electrical and Electronic Engineering, FE
Md. Abdullah Nabil
Masters in Electrical and Electronic Engineering, FE
Zahid Hasan Rifat
Masters in Electrical and Electronic Engineering, FE
Supervisors
Prof. Dr. Mohammad Nasir Uddin
Professor, Head [graduate Program], FE

Abstract

Cancer continues to be a major contributor to mortality worldwide, and timely diagnosis is essential for enhancing patient outcomes. A photonic crystal fiber surface plasmon resonance (PCF-SPR) biosensor is developed for rapid, label-free detection of PC-12 adrenal cancer cells. The design features a circular air-hole lattice combined with a thin gold layer, enabling enhanced plasmonic resonance under orthogonal polarizations. Finite element method (FEM) simulations reveal significant resonance wavelength shifts corresponding to refractive index differences between healthy and cancerous adrenal medulla cells. This sensing device demonstrates a wavelength sensitivity of 24,285.71 nm/RIU and amplitude sensitivity values of −2373.54 RIU⁻¹ and −2371.20 RIU⁻¹ for X and Y polarized modes, respectively. Performance evaluation confirms superior stability and polarization independence compared to existing PCF-SPR sensors. These results demonstrate the biosensor’s strong potential as an efficient platform for early-stage adrenal cancer diagnosis and real-time biomedical monitoring.

Keywords

Photonic crystal fiber (PCF) Surface plasmon resonance (SPR) Biosensor Cancer cell detection Wavelength sensitivity

Publication Details

  • Type of Publication:
  • Conference Name: ICTP 2025 – 6th IEEE International Conference on Telecommunications and Photonics
  • Date of Conference: 18/12/2025 - 18/12/2025
  • Venue: ECE Building, BUET, Dhaka-1205, Bangladesh
  • Organizer: IEEE Communication Society
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